反应详情

A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzothiazole, 0.28 g of potassium carbonate and 3 ml of methanol was refluxed with heating for 1.5 hours. The reaction mixture was cooled down to room temperature. To the reaction mixture was added water, and the resultant mixture was extracted with ethyl acetate twice. The combined organic layers were washed with water and saturated saline, dried over magnesium sulfate, then, concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, to obtain 2-(3-methoxypyridin-4-yl)-5-(trifluoromethyl)benzothiazole (hereinafter, referred to as the present compound 4).

1. temperaturewas refluxed
2. temperaturewith heating for 1.5 hours
3. extractionthe resultant mixture was extracted with ethyl acetate twice
4. washThe combined organic layers were washed with water and saturated saline
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure