反应详情

温度

0 °C

To a solution of 5-(4-fluoro-phenyl)-3-trimethylsilanylmethyl-3H-[1,2,3]triazole-4-carboxylic acid ethyl ester (880 mg, 2.74 mmol) in dry THF (8.2 mL) was added portionwise lithiumaluminiumhydride (119 mg, 3.15 mmol) at 0° C. and the reaction mixture was stirred at 0° C. for 1 h. Then water (119 μL) and NaOH (15%, 119 μL) was added followed by water (357 μL). The precipitate was then filtered off and the filtrate evaporated. Purification by chromatography (silica, 0 to 100% ethyl acetate in heptane) afforded the title compound (649 mg, 85%) as a white solid. MS: m/e=280.1 [M+H]+.

1. filtrationThe precipitate was then filtered off
2. customthe filtrate evaporated
3. customPurification by chromatography (silica, 0 to 100% ethyl acetate in heptane)