HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-pyridin-2-yl-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl)-methanol → [5-(5-Fluoro-pyridin-2-yl)-3-methyl-3H-[1,2,3]triazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-pyridin-2-yl-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl)-methanol | HCID 67498211 | — |
| Reactant | [5-(5-Fluoro-pyridin-2-yl)-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl]-methanol | HCID 67499018 | — |
| Product | [5-(5-Fluoro-pyridin-2-yl)-3-methyl-3H-[1,2,3]triazol-4-yl]-methanol | HCID 67499388 | 82.3% |
Reaction Steps
As described for example 25e, [5-(5-fluoro-pyridin-2-yl)-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl]-methanol (421 mg, 1.5 mmol), instead of (5-pyridin-2-yl-3-trimethylsilanylmethyl-3H-[1,2,3]triazol-4-yl)-methanol, was converted to the title compound (257 mg, 82%) which was obtained as a white solid. MS: m/e=209.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742097B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-b573b51fa4444109bc0abb36cef7c1d3 |
| Source note | uspto-grants-2014_06 |