2-Amino-2-methyl-1-propanol → HCID 57335095, compound

HRID 402401Notes

Reaction equation

HRID 402401 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[N:11][N:10]([CH3:13])[C:9]=2[CH2:14][O:15][C:16]2[N:21]=[N:20][C:19]([C:22](O)=[O:23])=[CH:18][CH:17]=2)=[CH:4][CH:3]=1.[NH2:25][C:26]([CH3:30])([CH3:29])[CH2:27][OH:28]>>[OH:28][CH2:27][C:26]([NH:25][C:22]([C:19]1[N:20]=[N:21][C:16]([O:15][CH2:14][C:9]2[N:10]([CH3:13])[N:11]=[N:12][C:8]=2[C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:17][CH:18]=1)=[O:23])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 67498530HCID 67498530, compound

Product 1

HCID 57335095HCID 57335095, compoundYield 40%

Procedure

As described for example 42b, 6-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyridazine-3-carboxylic acid (67 mg, 0.20 mmol) was converted, using 2-amino-2-methyl-1-propanol instead of 4-aminotetrahydropyran, to the title compound (37 mg, 40%) which was obtained as a white solid. MS: m/e=401.3 [M+H]+.

Sources & evidence

ORD record
ord-3f09e439c14d4864905ada05c4710a75
Source dataset
uspto-grants-2014_06
Patent number
US08742097B2

Reaction notes

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