1-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazole-5-carbaldehyde → (1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanol

HRID 402439Notes

Reaction equation

HRID 402439 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH:13]=[O:14])=[C:11]([CH3:15])[N:10]=[N:9]1.FC1C=CC(N2C(C=O)=C(C)N=N2)=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH2:13][OH:14])=[C:11]([CH3:15])[N:10]=[N:9]1

Participants

3

Reactant 2

HCID 199146531-(4-Fluorophenyl)-4-methyl-1H-1,2,3-triazole-5-carbaldehydeHCID 866647661-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazole-5-carbaldehyde

Product 1

HCID 67498340(1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanolYield 75%

Procedure

As described for example 60e, 1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazole-5-carbaldehyde (469 mg, 2.19 mmol), instead of 3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazole-4-carbaldehyde, was converted to the title compound (339 mg, 75%) which was obtained as a white solid. MS: m/e=208.1 [M+H]+.

Sources & evidence

ORD record
ord-0d2409a711a04fa3ab5fc1c26d590186
Source dataset
uspto-grants-2014_06
Patent number
US08742097B2

Reaction notes

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