Cyclopropanemethanamine → N-(Cyclopropylmethyl)-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamide

HRID 402446Notes

Reaction equation

HRID 402446 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH2:13][O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=2)=[C:11]([CH3:24])[N:10]=[N:9]1.[CH:25]1([CH2:28][NH2:29])[CH2:27][CH2:26]1>>[CH:25]1([CH2:28][NH:29][C:19](=[O:21])[C:18]2[CH:22]=[CH:23][C:15]([O:14][CH2:13][C:12]3[N:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])[N:9]=[N:10][C:11]=3[CH3:24])=[N:16][CH:17]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 75646CyclopropanemethanamineHCID 674984666-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid

Product 1

HCID 57335697N-(Cyclopropylmethyl)-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamideYield 60%

Procedure

As described for example 67, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (78 mg, 0.24 mmol), was converted, using cyclopropylmethylamine instead of isopropylamine, to the title compound (54 mg, 60%) which was obtained as a white gum. MS: m/e=382.3 [M+H]+.

Sources & evidence

ORD record
ord-f25a8f1e460f4934ade64e650a3c1202
Source dataset
uspto-grants-2014_06
Patent number
US08742097B2

Reaction notes

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