Cyclopropanemethanamine → N-(Cyclopropylmethyl)-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	Cyclopropanemethanamine	HCID 75646	—
Reactant	6-((1-(2-Fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid	HCID 67498466	—
Product	N-(Cyclopropylmethyl)-6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinamide	HCID 57335697	60%

Reaction Steps

As described for example 67, 6-((1-(2-fluorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinic acid (78 mg, 0.24 mmol), was converted, using cyclopropylmethylamine instead of isopropylamine, to the title compound (54 mg, 60%) which was obtained as a white gum. MS: m/e=382.3 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08742097B2
Source dataset	uspto-grants-2014_06
ORD ID	ord-f25a8f1e460f4934ade64e650a3c1202
Source note	uspto-grants-2014_06