Sarcosine → HCID 66632673, compound

HRID 402549Notes

Reaction equation

HRID 402549 reaction equation
[CH:1](=[C:8]1/[C:9](=[O:17])[NH:10][C:11]2[C:16]/1=[CH:15][CH:14]=[CH:13][CH:12]=2)\[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][NH:19][CH2:20]C(O)=O.[CH3:24][C:25]([CH3:29])=[CH:26][CH:27]=O>C1(C)C=CC=CC=1>[CH3:18][N:19]1[CH2:20][CH:1]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:8]2([C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]2=[O:17])[CH:27]1[CH:26]=[C:25]([CH3:29])[CH3:24]

Participants

5

Reactant 3

HCID 1088SarcosineHCID 610203-Methyl-2-butenalHCID 759029HCID 759029, compound

Product 1

HCID 66632673HCID 66632673, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3-E-3-benzylidene-1,3-dihydro-indol-2-one (10.0 mmol), N-methyl-glycine (14 mmol) and 3-methyl-but-2-enal (14 mmol) in 100 mL toluene was refluxed for 6 hours. The solvent was removed and the residue was purified on silica gel column to yield the product.

Workup

  1. temperaturewas refluxed for 6 hours
  2. customThe solvent was removed
  3. customthe residue was purified on silica gel column
  4. customto yield the product

Sources & evidence

ORD record
ord-384a3a6735e743518b428bc0def2a545
Source dataset
uspto-grants-2014_06
Patent number
US08742121B2

Reaction notes

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