Hydrochloric Acid → HCID 178469446, compound

HRID 402623Notes

Reaction equation

HRID 402623 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[O:9][CH2:10][C:11](=[O:18])[C:12]=2[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:4][CH2:3]1.[NH:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][N:26]=2)[C:21]([CH:28]=O)=[CH:20]1.CO.[ClH:32]>C(O)C>[ClH:32].[NH:19]1[C:27]2=[N:26][CH:25]=[CH:24][CH:23]=[C:22]2[C:21]([CH:28]=[C:10]2[O:9][C:8]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:11]2=[O:18])=[CH:20]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 53728121H-Pyrrolo[2,3-b]pyridine-3-carbaldehydeHCID 86708312HCID 86708312, compound

Product 1

HCID 178469446HCID 178469446, compoundYield 9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 2-(4-methylpiperazinyl)-4-oxo-4,5-dihydrofuran-3-carboxylate (0.038 g, 0.15 mmol) which similarly prepared according to the procedure described in the Example 4, First step and 7-azaindole-3-carboxaldehyde (0.022 g, 0.15 mmol) in ethanol (1.0 mL), 2M hydrochloric acid in methanol (0.17 mL, 0.34 mmol) was added at ambient temperature. The mixture was refluxed for 40 min. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol then dried to afford the titled compound as solid (0.0069 g, y. 9%).

Workup

  1. additionwas added at ambient temperature
  2. temperatureThe mixture was refluxed for 40 min
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with ethanol
  5. customthen dried

Sources & evidence

ORD record
ord-801b168a1a2e497ca97211fa9498cfbe
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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