HCID 178469571, compound → HCID 178516431, compound

HRID 402724Notes

Reaction equation

HRID 402724 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[O:15][C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:19][CH:18]=3)=[C:13](C(OCC)=O)[C:12]2=[O:34])=[CH:2]1>CN(C)C(=O)C.O>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[C:12](=[O:34])[CH:13]=[C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:21][CH:22]=3)[O:15]2)=[CH:2]1

Participants

4

Reactant 1

HCID 178469571HCID 178469571, compound

Product 1

HCID 178516431HCID 178516431, compoundYield 22.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Procedure

A solution of the compound (0.080 g, 0.17 mmol) of Example 42 in N,N-dimethylacetamide (3.0 mL) was stirred at 160° C. for 4 h. Cooled to ambient temperature, the reaction mixture was diluted with water and the precipitate was collected by filtration. The solid was washed with water, tetrahydrofuran and diethyl ether then dried to afford the titled compound as solid (0.015 g, y. 22%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washThe solid was washed with water, tetrahydrofuran and diethyl ether
  3. customthen dried

Sources & evidence

ORD record
ord-3e1fb28eafce43428ae7747b29e8994c
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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