HCID 178469749, compound → HCID 178516491, compound

HRID 402726Notes

Reaction equation

HRID 402726 reaction equation
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[O:15][C:14]([NH:16][CH2:17][C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)=[C:13](C(OCC)=O)[C:12]2=[O:28])=[CH:2]1>CN(C)C=O.C(Cl)(Cl)Cl>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH:10]=[C:11]2[C:12](=[O:28])[CH:13]=[C:14]([NH:16][CH2:17][C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)[O:15]2)=[CH:2]1

Participants

4

Reactant 1

HCID 178469749HCID 178469749, compound

Product 1

HCID 178516491HCID 178516491, compoundYield 22.6%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of the compound (0.10 g, 0.26 mmol) of Example 60 in N,N-dimethylformamide (0.80 mL) was refluxed for 16 h. Cooled to ambient temperature, the reaction mixture was diluted with chloroform and the precipitate was collected by filtration. The solid was washed with chloroform/methanol (10/1) and hexane then dried to afford the titled compound as solid (0.019 g, y. 22%).

Workup

  1. filtrationthe precipitate was collected by filtration
  2. washThe solid was washed with chloroform/methanol (10/1) and hexane
  3. customthen dried

Sources & evidence

ORD record
ord-4362dbd649c34c4f940dbf69f6da92e5
Source dataset
uspto-grants-2014_06
Patent number
US08742113B2

Reaction notes

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