Hydrochloric Acid → HCID 178438837, compound

HRID 402749Notes

Reaction equation

HRID 402749 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15]COC)[C:12]([CH:19]([CH3:21])[CH3:20])=[CH:11][C:10]=1[C:22]1[N:23]([C:28]2[CH:29]=[N:30][C:31]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[CH:32][CH:33]=2)[C:24]([OH:27])=[N:25][N:26]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:40]>CO>[ClH:40].[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([OH:15])[C:12]([CH:19]([CH3:21])[CH3:20])=[CH:11][C:10]=1[C:22]1[N:23]([C:28]2[CH:29]=[N:30][C:31]([N:34]3[CH2:39][CH2:38][O:37][CH2:36][CH2:35]3)=[CH:32][CH:33]=2)[C:24]([OH:27])=[N:25][N:26]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178498538HCID 178498538, compound

Product 1

HCID 178438837HCID 178438837, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the solution of compound (4) (2.10 g, 3.95 mmol) in MeOH (100 ml), HCl (2 ml, 2N) was added, and then the resultant mixture was heated at 65° C. for 5 h, then cooled. The white precipitate thus obtained was filtered, washed with ether (2×20 ml) gave 1.53 g (74%) of 5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride (5).

Workup

  1. temperaturecooled
  2. customThe white precipitate thus obtained
  3. filtrationwas filtered
  4. washwashed with ether (2×20 ml)

Sources & evidence

ORD record
ord-08d372358a444e24bee06647a295a7bc
Source dataset
uspto-grants-2014_06
Patent number
US08742133B2

Reaction notes

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