HCID 178438838, compound → HCID 178438836, compound

HRID 402750Notes

Reaction equation

HRID 402750 reaction equation
[P:1]([O:19][C:20]1[CH:25]=[C:24]([O:26]CC2C=CC=CC=2)[C:23]([C:34]2[N:38]([C:39]3[CH:40]=[N:41][C:42]([N:45]4[CH2:50][CH2:49][O:48][CH2:47][CH2:46]4)=[CH:43][CH:44]=3)[C:37]([OH:51])=[N:36][N:35]=2)=[CH:22][C:21]=1[CH:52]([CH3:54])[CH3:53])([O:11]CC1C=CC=CC=1)([O:3]CC1C=CC=CC=1)=[O:2]>CO.[Pd]>[P:1]([OH:3])([OH:11])([O:19][C:20]1[CH:25]=[C:24]([OH:26])[C:23]([C:34]2[N:38]([C:39]3[CH:40]=[N:41][C:42]([N:45]4[CH2:50][CH2:49][O:48][CH2:47][CH2:46]4)=[CH:43][CH:44]=3)[C:37]([OH:51])=[N:36][N:35]=2)=[CH:22][C:21]=1[CH:52]([CH3:54])[CH3:53])=[O:2]

Participants

4

Reactant 1

HCID 178438838HCID 178438838, compound

Product 1

HCID 178438836HCID 178438836, compoundYield 81%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Mixture (6) (2.3 g) was hydrogenated in MeOH (50 mL) using Pd/C (10%, dry, 200 mg) and H2 balloon at 1 atm at room temperature for 2 hr. Pd/C was filtered off through a pad of celite and the mother liquid was concentrated to give Compound 2 as white solid (1.13 g, 81%).

Workup

  1. customat room temperature
  2. customfor 2 hr
  3. filtrationPd/C was filtered off through a pad of celite
  4. concentrationthe mother liquid was concentrated

Sources & evidence

ORD record
ord-21a257f963254106b5971593c6cf9e57
Source dataset
uspto-grants-2014_06
Patent number
US08742133B2

Reaction notes

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