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Hydrochloric Acid → Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate | HCID 66766106 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt | HCID 66764605 | — |
反応手順
A solution of tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1.68 g, 4.3 mmol) in 4 N HCl in dioxane (20 mL) was stirred at room temperature for 1 hour to give a white suspension. Upon removal of the volatiles, the title compound was collected as its HCl salt as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08742110B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-024a152e703c4716a95cd0086c9eb472 |
| 出典メモ | uspto-grants-2014_06 |