Hydrochloric Acid → Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt

HRID 402755Notes

Reaction equation

HRID 402755 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[O:13][C:12]2=[O:28])=[CH:7][CH:6]=1)=[O:4].[ClH:29]>O1CCOCC1>[ClH:29].[O:28]=[C:12]1[N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=2)[CH2:15][C:14]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[O:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66766106Tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Product 1

HCID 66764605Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl 3-[4-(methoxycarbonyl)phenyl]-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1.68 g, 4.3 mmol) in 4 N HCl in dioxane (20 mL) was stirred at room temperature for 1 hour to give a white suspension. Upon removal of the volatiles, the title compound was collected as its HCl salt as a white solid.

Workup

  1. customto give a white suspension
  2. customUpon removal of the volatiles
  3. customthe title compound was collected as its HCl salt as a white solid

Sources & evidence

ORD record
ord-024a152e703c4716a95cd0086c9eb472
Source dataset
uspto-grants-2014_06
Patent number
US08742110B2

Reaction notes

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