HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40277Generated: October 25, 2026
Methanol → 1-(4-Bromo-2-chlorophenyl)ethanol
https://huagongshe.com/reaction/40277
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-(4-Bromo-2-chlorophenyl)ethan-1-one | HCID 15560950 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(4-Bromo-2-chlorophenyl)ethanol | HCID 20258128 | — |
Reaction Steps
To a stirring solution of 1-(4-bromo-2-chlorophenyl)ethanone (700 mg, 2998 μmol) in THF (20 mL) was added sodium borohydride (340 mg, 8994 μmol) and methanol (5 mL). Reaction suspension stirred overnight at 30° C. Reaction then partioned between EtOAc (50 mL) and sat NH4Cl (25 mL). Aqueous further extracted with EtOAc (2×25 mL). Combined organics dried over MgSO4, concentrated, then purified on silica (40 g) eluting with 10>40% EtOAc/hexanes. Product isolated as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08524900B2 |
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| Source dataset | uspto-grants-2013_09 |
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| ORD ID | ord-6e2f6a2df23743e3a6bd3337a6705800 |
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| Source note | uspto-grants-2013_09 |
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