反应详情

温度

30 °C

To a stirring solution of 1-(4-bromo-2-chlorophenyl)ethanone (700 mg, 2998 μmol) in THF (20 mL) was added sodium borohydride (340 mg, 8994 μmol) and methanol (5 mL). Reaction suspension stirred overnight at 30° C. Reaction then partioned between EtOAc (50 mL) and sat NH4Cl (25 mL). Aqueous further extracted with EtOAc (2×25 mL). Combined organics dried over MgSO4, concentrated, then purified on silica (40 g) eluting with 10>40% EtOAc/hexanes. Product isolated as a colorless oil.

1. customReaction suspension
2. customReaction
3. extractionAqueous further extracted with EtOAc (2×25 mL)
4. dry with materialCombined organics dried over MgSO4
5. concentrationconcentrated
6. custompurified on silica (40 g)
7. washeluting with 10>40% EtOAc/hexanes
8. customProduct isolated as a colorless oil