反应详情

To a stirring solution of (4-bromo-2-chlorophenyl)methanol (4.5 g, 20 mmol) in DCM (50 mL) was added Dess-Martin periodinane (9.3 g) at 23° C. Reaction refluxed after addition. After 20 min, TLC (1:4 EtOAc/Hex) suggests full conversion of alcohol. Suspension then washed with 5% NaHCO3 (100 mL plus 15 g dry NaHCO3). Organic dried over MgSO4, concentrated onto dry silica (15 g), then purified on silica (120 g) eluting with 0>10% EtOAc/hex. 4-bromo-2-chlorobenzaldehyde isolated as a white solid.

1. customReaction
2. temperaturerefluxed
3. additionafter addition
4. washSuspension then washed with 5% NaHCO3 (100 mL plus 15 g dry NaHCO3)
5. dry with materialOrganic dried over MgSO4
6. concentrationconcentrated onto dry silica (15 g)
7. custompurified on silica (120 g)
8. washeluting with 0>10% EtOAc/hex