Dimethylformamide → HCID 77230854, compound

HRID 402790Notes

Reaction equation

HRID 402790 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=1)[O:8][C:7]([CH3:14])([CH3:13])[CH2:6][CH2:5]2.[Li]CCCC.CN([CH:23]=[O:24])C>>[CH3:13][C:7]1([CH3:14])[CH2:6][CH2:5][C:4]2[C:9](=[C:10]([CH3:12])[CH:11]=[C:2]([CH:23]=[O:24])[CH:3]=2)[O:8]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 66764890HCID 66764890, compoundHCID 178418339Butyllithium

Product 1

HCID 77230854HCID 77230854, compound

Procedure

Using essentially the same procedure as Example 5-20, Step 3, 6-bromo-2,2,8-trimethyl-3,4-dihydro-2H-chromene (684 mg, 2.68 mmol), n-BuLi (1.30 mL, 3.22 mmol) and DMF (830 μL, 10.7 mmol) afforded the desired product as a pale-yellow oil.

Sources & evidence

ORD record
ord-0c4d1fafe2d84d198095c9c9aa4593bc
Source dataset
uspto-grants-2014_06
Patent number
US08742110B2

Reaction notes

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