反应详情

温度

37 °C

A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.

1. customReaction
2. filtrationfiltered through Celite, and solid
3. washwashed repeatedly with DCM
4. concentrationFiltrate concentrated
5. customthen purified on silica (80 g)
6. washeluting product with 0>30% of EtOAc/Hex