Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt → Methyl 4-[8-(3,5-dibromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate
Reaction equation
Cl.[O:2]=[C:3]1[N:7]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][C:5]2([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[O:4]1.[Br:23][C:24]1[CH:29]=[C:28]([CH2:30]Br)[CH:27]=[C:26]([Br:32])[C:25]=1[Cl:33]>>[Br:23][C:24]1[CH:29]=[C:28]([CH:27]=[C:26]([Br:32])[C:25]=1[Cl:33])[CH2:30][N:20]1[CH2:21][CH2:22][C:5]2([O:4][C:3](=[O:2])[N:7]([C:8]3[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=3)[CH2:6]2)[CH2:18][CH2:19]1Participants
3
Procedure
The title compound was prepared from methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt (100 mg, 0.306 mmol; Example 1, Step 2) and 1,3-dibromo-5-(bromomethyl)-2-chlorobenzene (122 mg, 0.337 mmol) following essentially the same procedure described in Step 1 of Example 7-9. The title compound was obtained as a white solid (175 mg) and was used without further purification.
Sources & evidence
- ORD record
- ord-27e83d5ac87d4b0393d9f41d753ac820
- Source dataset
- uspto-grants-2014_06
- Patent number
- US08742110B2
Reaction notes
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