Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt → Methyl 4-[8-(3,5-dibromo-4-chlorobenzyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl]benzoate

Participants

Reaction Steps

The title compound was prepared from methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt (100 mg, 0.306 mmol; Example 1, Step 2) and 1,3-dibromo-5-(bromomethyl)-2-chlorobenzene (122 mg, 0.337 mmol) following essentially the same procedure described in Step 1 of Example 7-9. The title compound was obtained as a white solid (175 mg) and was used without further purification.

Provenance & Evidence