4-Chloro-3-(trifluoromethoxy)benzaldehyde → HCID 66764824, compound

HRID 402835Notes

Reaction equation

HRID 402835 reaction equation
Cl.[O:2]=[C:3]1[N:7]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][C:5]2([CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[O:4]1.[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][C:25]=1[O:32][C:33]([F:36])([F:35])[F:34]>>[Cl:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:20]2[CH2:21][CH2:22][C:5]3([O:4][C:3](=[O:2])[N:7]([C:8]4[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=4)[CH2:6]3)[CH2:18][CH2:19]2)=[CH:26][C:25]=1[O:32][C:33]([F:34])([F:36])[F:35]

Participants

3

Reactant 2

HCID 177507904-Chloro-3-(trifluoromethoxy)benzaldehydeHCID 66764605Methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt

Product 1

HCID 66764824HCID 66764824, compound

Procedure

The title compound was prepared from methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt (50 mg, 0.153 mmol; Example 1, Step 2) and 4-chloro-3-trifluoromethoxybenzaldehyde (43.7 mg, 0.199 mmol) following essentially the same procedure described in Step 1 of Example 7-6. The title compound was obtained as a yellow oil (76 mg) that was used without any further purification.

Sources & evidence

ORD record
ord-bcd11741f97c45b1a40f5b44a28bf327
Source dataset
uspto-grants-2014_06
Patent number
US08742110B2

Reaction notes

Loading…