Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 402835Generated: October 30, 2026

4-Chloro-3-(trifluoromethoxy)benzaldehyde → HCID 66764824, compound

https://huagongshe.com/reaction/402835

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-3-(trifluoromethoxy)benzaldehydeHCID 17750790—
ReactantMethyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride saltHCID 66764605—
ProductHCID 66764824HCID 66764824—

Reaction Steps

The title compound was prepared from methyl 4-(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-3-yl)benzoate hydrochloride salt (50 mg, 0.153 mmol; Example 1, Step 2) and 4-chloro-3-trifluoromethoxybenzaldehyde (43.7 mg, 0.199 mmol) following essentially the same procedure described in Step 1 of Example 7-6. The title compound was obtained as a yellow oil (76 mg) that was used without any further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08742110B2
Source datasetuspto-grants-2014_06
ORD IDord-bcd11741f97c45b1a40f5b44a28bf327
Source noteuspto-grants-2014_06