Tetrahydrofuran → HCID 66764840, compound

HRID 402839Notes

Reaction equation

HRID 402839 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[I:11])[C:5](O)=[O:6].C1COCC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[I:11])[CH2:5][OH:6]

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 199713023,5-Dichloro-4-iodobenzoic acid

Product 1

HCID 66764840HCID 66764840, compound

Procedure

Using essentially the same procedure as for Example 8-1, Step 2, 3,5-dichloro-4-iodobenzoic acid (1900 mg, 6.0 mmol) was reduced to the title intermediate (1050 mg) using 2M borane-methyl sulfide complex in THF (4.0 mL, 8.0 mmol).

Sources & evidence

ORD record
ord-d96403f1ec904b2396732684e224268c
Source dataset
uspto-grants-2014_06
Patent number
US08742110B2

Reaction notes

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