Potassium Carbonate → HCID 86686850, compound

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Reaction Steps

A solution of acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-[8-(1′-methyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-6-ylamino)-imidazo[1,2-a]pyridin-6-yl]-benzyl ester (270 mg, 0.4012 mmol) and K2CO3 (166 mg, 1.2036 mmol) in CH3OH (15 mL) was stirred at room temperature for 3 h. TLC showed a complete reaction. The solution was poured onto water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated to give the desired product (200 mg) with high purity.

Provenance & Evidence