Potassium Carbonate → HCID 86686850, compound

HRID 402953Notes

Reaction equation

HRID 402953 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]3[CH:29]=[C:30]([NH:37][C:38]4[N:43]=[CH:42][C:41]([CH:44]5[CH2:49][CH2:48][N:47]([CH3:50])[CH2:46][CH2:45]5)=[CH:40][CH:39]=4)[C:31]4[N:32]([CH:34]=[CH:35][N:36]=4)[CH:33]=3)[C:18]=1[CH2:19][O:20]C(=O)C)[N:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2].C([O-])([O-])=O.[K+].[K+]>CO>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]3[CH:29]=[C:30]([NH:37][C:38]4[N:43]=[CH:42][C:41]([CH:44]5[CH2:49][CH2:48][N:47]([CH3:50])[CH2:46][CH2:45]5)=[CH:40][CH:39]=4)[C:31]4[N:32]([CH:34]=[CH:35][N:36]=4)[CH:33]=3)[C:18]=1[CH2:19][OH:20])[N:9]=[CH:8]2)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86686851HCID 86686851, compound

Product 1

HCID 86686850HCID 86686850, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-[8-(1′-methyl-1′,2′,3′,4′,5′,6′-hexahydro-[3,4′]bipyridinyl-6-ylamino)-imidazo[1,2-a]pyridin-6-yl]-benzyl ester (270 mg, 0.4012 mmol) and K2CO3 (166 mg, 1.2036 mmol) in CH3OH (15 mL) was stirred at room temperature for 3 h. TLC showed a complete reaction. The solution was poured onto water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, and concentrated to give the desired product (200 mg) with high purity.

Workup

  1. customa complete reaction
  2. additionThe solution was poured onto water
  3. extractionextracted with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-6b37b84a09f748b4969fc036244b047b
Source dataset
uspto-grants-2014_06
Patent number
US08742098B2

Reaction notes

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