HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → L-Methionine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | 2-Amino-4-bromobutanoic acid hydrobromide | HCID 13877992 | — |
| Product | L-Methionine | HCID 6137 | 82% |
| Product | L-Homoserine | HCID 12647 | 2.6% |
Reaction Steps
4-Bromo-2-aminobutanoic acid hydrobromide (1 eq.) was treated with sodium methane thiolate (3.2 eq.) in DMSO (25 eq.) at 80° C. for 1 hour. Methionine (82% yield) and homoserine (2.6% yield) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08742170B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-a4ac0a7adf914a1885be15bf342be42a |
| Source note | uspto-grants-2014_06 |