Methanesulfonic Acid → HCID 86612960, compound

HRID 403056Notes

Reaction equation

HRID 403056 reaction equation
[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:27]=[C:26]([CH3:28])[O:25][N:24]=4)=[CH:17][CH:16]=3)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:31][S:32]([OH:35])(=[O:34])=[O:33]>>[CH3:31][S:32]([OH:35])(=[O:34])=[O:33].[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]4[CH:27]=[C:26]([CH3:28])[O:25][N:24]=4)=[CH:19][CH:20]=3)[CH:7]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11463864HCID 11463864, compound

Product 1

HCID 86612960HCID 86612960, compound

Procedure

Using an analogous procedure to that described in Example 36, N-cyclopropyl-4-methyl-3-({4-[(5-methylisoxazol-3-yl)methoxy]benzoyl}amino)benzamide was reacted with methanesulfonic acid to give the title compound: NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.68 (m, 2H), 2.26 (s, 3H), 2.44 (s, 3H), 2.52 (s, 3H), 2.85 (m, 1H), 5.25 (s, 2H), 6.37 (s, 1H), 7.15 (m, 2H), 7.31 (m, 1H), 7.61 (m, 1H), 7.78 (s, 1H), 7.98 (m, 2H), 8.37 (s, 1H), 9.82 (s, 1H), 12.12 (br s, 1H); Mass Spectrum: M−H− 404, M+Na+ 428.

Sources & evidence

ORD record
ord-b51ec038620d47cb87e69162061eb138
Source dataset
uspto-grants-2014_06
Patent number
US08742124B2

Reaction notes

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