Hydrochloric Acid → N-cyclopropyl-4-methyl-3-{[4-(pyridin-2-ylmethoxy)benzoyl]amino}benzamide hydrochloride

HRID 403057Notes

Reaction equation

HRID 403057 reaction equation
[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[CH:17][CH:16]=3)[CH:7]=2)[CH2:3][CH2:2]1.[ClH:31]>>[ClH:31].[CH:1]1([NH:4][C:5](=[O:30])[C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([NH:13][C:14](=[O:29])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[CH:17][CH:16]=3)[CH:7]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11475107N-cyclopropyl-4-methyl-3-{[4-(pyridin-2-ylmethoxy)benzoyl]amino}benzamide

Product 1

HCID 66630639N-cyclopropyl-4-methyl-3-{[4-(pyridin-2-ylmethoxy)benzoyl]amino}benzamide hydrochloride

Procedure

Using an analogous procedure to that described in Example 36, N-cyclopropyl-4-methyl-3-{[4-(pyridin-2-ylmethoxy)benzoyl]amino}benzamide was reacted with hydrochloric acid to give the title compound; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.68 (m, 2H), 2.24 (s, 3H), 2.86 (m, 1H), 5.44 (s, 2H), 7.18 (d, 2H), 7.32 (m, 1H), 7.65 (m, 2H), 7.81 (m, 2H), 7.98 (d, 2H), 8.19 (m, 1H), 8.36 (m, 1H), 8.73 (m, 1H), 9.85 (s, 1H); Mass Spectrum: M+H+ 401.

Sources & evidence

ORD record
ord-a8d417d1d3654263a09a1911834feb26
Source dataset
uspto-grants-2014_06
Patent number
US08742124B2

Reaction notes

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