Methanesulfonic Acid → HCID 86660789, compound

HRID 403060Notes

Reaction equation

HRID 403060 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:31])=[C:11]([NH:13][C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[C:17]([F:29])[CH:16]=3)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:32][S:33]([OH:36])(=[O:35])=[O:34]>>[CH3:32][S:33]([OH:36])(=[O:35])=[O:34].[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:31])=[C:11]([NH:13][C:14](=[O:30])[C:15]3[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)=[C:17]([F:29])[CH:16]=3)[CH:12]=2)=[O:6])[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11154338HCID 11154338, compound

Product 1

HCID 86660789HCID 86660789, compound

Procedure

Using an analogous procedure to that described in Example 36, N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide was reacted with methanesulfonic acid to give the title compound; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.68 (m, 2H), 2.25 (s, 3H), 2.40 (s, 3H), 2.86 (m, 1H), 5.51 (s, 2H), 7.32 (m, 1H), 7.42 (m, 1H), 7.63 (m, 1H), 7.73 (m, 1H), 7.78 (s, 1H), 7.86 (m, 3H), 8.25 (m, 1H), 8.37 (m, 1H), 8.78 (m, 1H), 9.95 (s, 1H); Mass Spectrum: M+H+ 420.

Sources & evidence

ORD record
ord-069a87fd060f4ed0820bc7953d57cc21
Source dataset
uspto-grants-2014_06
Patent number
US08742124B2

Reaction notes

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