HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Tert-butyl-2-((2-tert-butoxybenzyl)(6-(4-(2-methoxyphenyl)piperidin-1-yl)hexyl)amino)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methoxy-4-phenylpiperidine | HCID 67128244 | — |
| Reactant | Tert-butyl 2-((2-tert-butoxybenzyl)(6-(4-phenylpiperidin-1-yl)hexyl)amino)ethylcarbamate | HCID 70896342 | — |
| Reactant | Tert-butyl 2-((6-bromohexyl)(2-tert-butoxybenzyl)amino)ethylcarbamate | HCID 86672687 | — |
| Product | Tert-butyl-2-((2-tert-butoxybenzyl)(6-(4-(2-methoxyphenyl)piperidin-1-yl)hexyl)amino)ethylcarbamate | HCID 131731436 | 63.4% |
Reaction Steps
The same procedure as described for compound 16 was applied to starting material 15 (1.9 g, 4.66 mmol), 2-methoxy-4-phenylpiperidin (1.338 g, 6.99 mmol) and K2CO3 (0.644 g, 4.66 mmol). Purification was carried out on a silica gel TLC plate that was developed in with a 3% methanolic NH3 (7 M NH3 in methanol/97% CH2Cl2. The product was isolated as pale yellow oil (63.4%). Mass Spec.=596.44 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08747810B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-32d43d4e5a634f8091ce0d5af64aefad |
| Source note | uspto-grants-2014_06 |