HRID403123

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID67128244

未命名化合物

结构：CC(C)(C)OC(=O)NCCN(CCCCCCN1CCC(c2ccccc2)CC1)Cc1ccccc1OC(C)(C)C

HCID70896342

未命名化合物

结构：CC(C)(C)OC(=O)NCCN(CCCCCCBr)Cc1ccccc1OC(C)(C)C

HCID86672687

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1C1CCN(CCCCCCN(CCNC(=O)OC(C)(C)C)Cc2ccccc2OC(C)(C)C)CC1

HCID131731436

未命名化合物

收率 63.4%

PROCEDURE

实验过程

The same procedure as described for compound 16 was applied to starting material 15 (1.9 g, 4.66 mmol), 2-methoxy-4-phenylpiperidin (1.338 g, 6.99 mmol) and K2CO3 (0.644 g, 4.66 mmol). Purification was carried out on a silica gel TLC plate that was developed in with a 3% methanolic NH3 (7 M NH3 in methanol/97% CH2Cl2. The product was isolated as pale yellow oil (63.4%). Mass Spec.=596.44 (M+H)+.

WORKUP

后处理

customPurification

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-32d43d4e5a634f8091ce0d5af64aefad
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08747810B2
来源说明: uspto-grants-2014_06

反应 SMILES

[C:1]([O:5][C:6]1[CH:41]=[CH:40][CH:39]=[CH:38][C:7]=1[CH2:8][N:9]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:27]1)[CH2:10][CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:4])([CH3:3])[CH3:2].BrCCCCCCN(CC1C=CC=CC=1OC(C)(C)C)CCN[C:53](=O)[O:54]C(C)(C)C.COC1CC(C2C=CC=CC=2)CCN1.C([O-])([O-])=O.[K+].[K+]>>[C:15]([O:14][C:13](=[O:19])[NH:12][CH2:11][CH2:10][N:9]([CH2:8][C:7]1[CH:38]=[CH:39][CH:40]=[CH:41][C:6]=1[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26]1[CH2:31][CH2:30][CH:29]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:37]=2[O:54][CH3:53])[CH2:28][CH2:27]1)([CH3:18])([CH3:17])[CH3:16]