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温度

0 °C

To a solution of ethyl 6-[1-(tert-butoxycarbonyl)piperidin-4-yl]pyridine-2-carboxylate (2.0 g) was added dropwise, at 0° C., a 4 molar solution of hydrochloric acid in 1,4-dioxane (45 ml). The reaction mixture was stirred at 0° C. and then gradually warmed to room temperature. After stirring overnight, the solvent and excess hydrogen chloride were removed. This gave 4-[6-(ethoxycarbonyl)pyridin-2-yl]piperidinium chloride (1.75 g).

1. temperaturegradually warmed to room temperature
2. stirringAfter stirring overnight
3. customthe solvent and excess hydrogen chloride were removed