反应详情

温度

110 °C

A 500 mL RB flask was charged with 6-chloropyridazin-3-amine (10.0 g, 77.2 mmol) and dimethoxy-N,N-dimethylmethanamine (206 ml, 1544 mmol), equipped with a reflux condenser, then heated to 110° C. for 3 hours then left at room temperature for 16 hours. The precipitate was collected by filtration. The mother liqour was concentrated down to give an yellow solid, which was triturated with EtOAc and collected. The solids were combined to give (E)-N′-(6-chloropyridazin-3-yl)-N,N-dimethylformamidine (11.81 g, 82.9% yield) as a white solid

1. customequipped with a reflux condenser
2. filtrationThe precipitate was collected by filtration
3. concentrationThe mother liqour was concentrated down
4. customto give an yellow solid, which
5. customwas triturated with EtOAc
6. customcollected