Trifluoroacetic acid → HCID 67289029, compound

HRID 403283Notes

Reaction equation

HRID 403283 reaction equation
[C:1]([N:9]1[CH2:13][CH2:12][C@H:11]([N:14](C)[C:15](=O)OC(C)(C)C)[CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:15][NH:14][C@H:11]1[CH2:12][CH2:13][N:9]([C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:8])[CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67473782HCID 67473782, compound

Product 1

HCID 67289029HCID 67289029, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of compound 4c (0.12 g, 0.394 mmol) in CH2Cl2 (3 mL) was added trifluoroacetic acid (1 mL) at room temperature. The mixture was stirred at room temperature for 5 h. The solvent was removed by evaporation. Ether (10 mL) was added to the residue. The crude product was collected by filtration, washed with ether, and dried under vacuum. MS m/z (M+H+) 205.2.

Workup

  1. customThe solvent was removed by evaporation
  2. additionEther (10 mL) was added to the residue
  3. filtrationThe crude product was collected by filtration
  4. washwashed with ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-95a573e5922f456fbcd28a3780e19dc2
Source dataset
uspto-grants-2014_06
Patent number
US08748417B2

Reaction notes

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