HCID 71766083, compound → N-(6-Chloro-4-o-tolyl-pyridazin-3-yl)-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide

HRID 403375Notes

Reaction equation

HRID 403375 reaction equation
Cl[C:2]1N=NC(NC)=C(C2C=CC=CC=2C)C=1.[Cl:17][C:18]1[N:23]=[N:22][C:21]([N:24]([CH3:41])[C:25](=[O:40])[C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([S:36]([CH3:39])(=[O:38])=[O:37])[CH:27]=2)=[C:20]([C:42]2[CH:47]=[CH:46][C:45](F)=[CH:44][C:43]=2OC)[CH:19]=1>>[Cl:17][C:18]1[N:23]=[N:22][C:21]([N:24]([CH3:41])[C:25](=[O:40])[C:26]2[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[C:28]([S:36]([CH3:39])(=[O:37])=[O:38])[CH:27]=2)=[C:20]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][C:43]=2[CH3:2])[CH:19]=1

Participants

3

Reactant 2

HCID 71766083HCID 71766083, compound2×HCID 866984766-chloro-N-methyl-4-o-tolylpyridazin-3-amine

Product 1

HCID 71766085N-(6-Chloro-4-o-tolyl-pyridazin-3-yl)-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide

Procedure

The title compound was prepared in analogy to example 1, from (6-chloro-4-o-tolyl-pyridazin-3-yl)-methyl-amine and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 1, intermediate d) after a reaction time of 18 hours, applying a second purification step using preparative HPLC (Gemini NX column) with a gradient of methanol:water with 0.05% formic acid (80:20 to 98:2). Colorless foam (23%). MS (ESI+): m/z=484.070 ([M+H]+).

Workup

  1. customa second purification step

Sources & evidence

ORD record
ord-ed8c49a297364d5e83a5ffdd6aeaa620
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

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