HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 71766083, compound → N-(6-Chloro-4-o-tolyl-pyridazin-3-yl)-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 71766083 | HCID 71766083 | — |
| Reactant | 6-chloro-N-methyl-4-o-tolylpyridazin-3-amine | HCID 86698476 | — |
| Product | N-(6-Chloro-4-o-tolyl-pyridazin-3-yl)-3-methanesulfonyl-N-methyl-5-trifluoromethyl-benzamide | HCID 71766085 | — |
Reaction Steps
The title compound was prepared in analogy to example 1, from (6-chloro-4-o-tolyl-pyridazin-3-yl)-methyl-amine and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 1, intermediate d) after a reaction time of 18 hours, applying a second purification step using preparative HPLC (Gemini NX column) with a gradient of methanol:water with 0.05% formic acid (80:20 to 98:2). Colorless foam (23%). MS (ESI+): m/z=484.070 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748434B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-ed8c49a297364d5e83a5ffdd6aeaa620 |
| Source note | uspto-grants-2014_06 |