(2-Methoxypyridin-3-yl)boronic acid → 6-Chloro-4-(2-methoxypyridin-3-yl)pyridazin-3-ylamine

HRID 403387Notes

Reaction equation

HRID 403387 reaction equation
Br[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[N:4][C:3]=1[NH2:9].[CH3:10][O:11][C:12]1[C:17](B(O)O)=[CH:16][CH:15]=[CH:14][N:13]=1>>[Cl:8][C:6]1[N:5]=[N:4][C:3]([NH2:9])=[C:2]([C:17]2[C:12]([O:11][CH3:10])=[N:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 2762709(2-Methoxypyridin-3-yl)boronic acidHCID 220244193-Amino-4-bromo-6-chloropyridazine

Product 1

HCID 866984806-Chloro-4-(2-methoxypyridin-3-yl)pyridazin-3-ylamine

Procedure

The title compound was prepared in analogy to example 1, intermediate b, from 4-bromo-6-chloropyridazin-3-amine (CAS RN 446273-59-2) and 2-methoxypyridine-3-boronic acid (CAS RN 163105-90-6) after a reaction time of 18 hours. Brown solid (49%). MS (ESI+): m/z=237.054 ([M+H]+).

Sources & evidence

ORD record
ord-70da0f2f0f8a4a0f83c8784e128cb599
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

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