Dichloromethane methanol → HCID 86698483, compound

HRID 403396Notes

Reaction equation

HRID 403396 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([NH2:14])=[CH:10][N:11]=[N:12][CH:13]=2)=[C:4]([O:15][CH3:16])[CH:3]=1.Cl[CH2:18]Cl.CO>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([NH:14][CH3:18])=[CH:10][N:11]=[N:12][CH:13]=2)=[C:4]([O:15][CH3:16])[CH:3]=1

Participants

3

Reactant 2

HCID 21226129Dichloromethane methanolHCID 866984845-(4-Fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine

Product 1

HCID 86698483HCID 86698483, compound

Procedure

The title compound was prepared in analogy to example 1, intermediate a, from 5-(4-fluoro-2-methoxy-phenyl)-pyridazin-4-ylamine and using a gradient of dichloromethane:methanol (100:0 to 90:10) for the chromatographic purification. Brown oil (5%). MS (ESI+): m/z=234.1 ([M+H]+).

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-1149b2e61e49497fa7ff7f28ecae83d8
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

Loading…