Ethylacetate heptane → N-methyl-5-o-tolylpyridazin-4-amine

HRID 403399Notes

Reaction equation

HRID 403399 reaction equation
[C:1]1([CH3:14])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:8]([NH2:13])=[CH:9][N:10]=[N:11][CH:12]=1.[CH3:15]CCCCCC.C(OCC)(=O)C>>[CH3:15][NH:13][C:8]1[C:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:14])=[CH:12][N:11]=[N:10][CH:9]=1

Participants

3

Reactant 2

HCID 21899848Ethylacetate heptaneHCID 866984865-o-Tolyl-pyridazin-4-ylamine

Product 1

HCID 86698485N-methyl-5-o-tolylpyridazin-4-amine

Procedure

The title compound was prepared in analogy to example 8, intermediate a, from 5-o-tolyl-pyridazin-4-ylamine and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. Light yellow solid (71%). MS (EI): m/z=199 ([M]).

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-b300b1dcb67c41b4b5db2a5e547945c4
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

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