2-Methylphenyl boronic acid → 5-o-Tolyl-pyridazin-4-ylamine

HRID 403400Notes

Reaction equation

HRID 403400 reaction equation
Cl[C:2]1[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=1.[CH3:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O>>[C:10]1([CH3:9])[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:2]1[C:3]([NH2:8])=[CH:4][N:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 130010635-Chloropyridazin-4-amine

Product 1

HCID 866984865-o-Tolyl-pyridazin-4-ylamine

Procedure

The title compound was prepared in analogy to example 1, intermediate b, from 5-chloro-pyridazin-4-ylamine (CAS RN 53180-92-0) and 2-methylphenylboronic acid (CAS RN). Light yellow solid (37%). MS (ESI+): m/z=186.103 ([M+H]+).

Sources & evidence

ORD record
ord-49b8742bb2c24677ad608e77e44cdb37
Source dataset
uspto-grants-2014_06
Patent number
US08748434B2

Reaction notes

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