Stannous Chloride → [4-(2-Ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-hydrazine

HRID 403491Notes

Reaction equation

HRID 403491 reaction equation
[CH2:1]([C:3]1[C:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]#[N:22])=[CH:17][CH:16]=2)=[C:6]2[N:7]=[C:8]([CH3:12])[CH:9]=[C:10]([CH3:11])[N:5]2[N:4]=1)[CH3:2].[Sn](Cl)Cl>Cl>[CH2:1]([C:3]1[C:13]([CH2:14][C:15]2[CH:16]=[CH:17][C:18]([NH:21][NH2:22])=[CH:19][CH:20]=2)=[C:6]2[N:7]=[C:8]([CH3:12])[CH:9]=[C:10]([CH3:11])[N:5]2[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 866717544-(2-Ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-benzenediazonium

Product 1

HCID 68390855[4-(2-Ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-phenyl]-hydrazine

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The crude 4-(2-ethyl-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-3-ylmethyl)-benzenediazonium salt (14) (1.8 g, 6.16 mmol) was dissolved in 40 ml of conc. HCl. After addition of tin(II)chloride (1.75 g, 9.24 mmol) the reaction mixture was stirred for 30 min at r.t. The reaction mixture was concentrated and used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customused in the next step without further purification

Sources & evidence

ORD record
ord-1bcabfd04f284d57a5d1370ad39b5af7
Source dataset
uspto-grants-2014_06
Patent number
US08748435B2

Reaction notes

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