HRID40353

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734338

3,5-Difluorophenylboronic acid

C6H5BF2O2

结构：COc1cnc2ccc(C(F)(F)c3nnc4c(F)cc(-c5cc(F)cc(F)c5)cn34)cc2c1

HCID57691053

未命名化合物

结构：COCCOc1cnc2ccc(C(F)(F)c3nnc4ccc(Cl)nn34)cc2c1

HCID57691391

未命名化合物

PRODUCTS

生成物

结构：COCCOc1cnc2ccc(C(F)(F)c3nnc4ccc(-c5cc(F)cc(F)c5)nn34)cc2c1

HCID57691113

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized from 6-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)-3-(2-methoxyethoxy)quinoline and 3,5-difluorophenylboronic acid in a similar manner as that described for 6-((6-(3,5-difluorophenyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)-3-methoxyquinoline. LRMS (ESI) m/z calcd for C24H18F4N5O2 (M+H) 484.1. found 484.2.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0551259eb35746e8b1a1855fcd245a14
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08524900B2
来源说明: uspto-grants-2013_09

反应 SMILES

Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:11]([F:28])([F:27])[C:12]3[CH:13]=[C:14]4[C:19](=[CH:20][CH:21]=3)[N:18]=[CH:17][C:16]([O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:15]4)=[N:9][N:10]=2)[N:7]=1.[F:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[C:34]([F:36])[CH:35]=1.FC1C=C(C2C=C(F)C3N(C(C(F)(F)C4C=C5C(=CC=4)N=CC(OC)=C5)=NN=3)C=2)C=C(F)C=1>>[F:29][C:30]1[CH:31]=[C:32]([C:2]2[CH:3]=[CH:4][C:5]3[N:6]([C:8]([C:11]([F:28])([F:27])[C:12]4[CH:13]=[C:14]5[C:19](=[CH:20][CH:21]=4)[N:18]=[CH:17][C:16]([O:22][CH2:23][CH2:24][O:25][CH3:26])=[CH:15]5)=[N:9][N:10]=3)[N:7]=2)[CH:33]=[C:34]([F:36])[CH:35]=1