化工社化工社 化学情報印刷レポート · 研究参考用
(3,5-Difluorophenyl)boronic acid → 6-((6-(3,5-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)-3-(2-methoxyethoxy)quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| 反応物 | 6-((6-(3,5-Difluorophenyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)-3-methoxyquinoline | HCID 57691053 | — |
| 反応物 | 6-((6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)-3-(2-methoxyethoxy)quinoline | HCID 57691391 | — |
| 生成物 | 6-((6-(3,5-Difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)-3-(2-methoxyethoxy)quinoline | HCID 57691113 | — |
反応手順
The title compound was synthesized from 6-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)difluoromethyl)-3-(2-methoxyethoxy)quinoline and 3,5-difluorophenylboronic acid in a similar manner as that described for 6-((6-(3,5-difluorophenyl)-8-fluoro-[1,2,4]triazolo[4,3-a]pyridin-3-yl)difluoromethyl)-3-methoxyquinoline. LRMS (ESI) m/z calcd for C24H18F4N5O2 (M+H) 484.1. found 484.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08524900B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-0551259eb35746e8b1a1855fcd245a14 |
| 出典メモ | uspto-grants-2013_09 |