4-t-Butylbenzenesulfonyl chloride → HCID 10152782, compound

HRID 403539Notes

Reaction equation

HRID 403539 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[C:5](=[O:25])[N:6]([C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[C:7]([CH:13]([NH:15][CH3:16])[CH3:14])=[N:8]2.[C:26]([C:30]1[CH:35]=[CH:34][C:33]([S:36](Cl)(=[O:38])=[O:37])=[CH:32][CH:31]=1)([CH3:29])([CH3:28])[CH3:27]>>[C:26]([C:30]1[CH:35]=[CH:34][C:33]([S:36]([N:15]([CH:13]([C:7]2[N:6]([C:17]3[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=3)[C:5](=[O:25])[C:4]3[C:9](=[CH:10][CH:11]=[CH:12][C:3]=3[O:2][CH3:1])[N:8]=2)[CH3:14])[CH3:16])(=[O:38])=[O:37])=[CH:32][CH:31]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 66689784HCID 66689784, compound

Product 1

HCID 10152782HCID 10152782, compound

Procedure

In a similar manner as described above in Paragraph A, 5-methoxy-3-(4-methoxyphenyl)-2-(1-methylaminoethyl)-3H-quinazolin-4-one, as prepared above in Example 5, was condensed with 4-tert-butylbenzenesulfonyl chloride to yield 4-tert-butyl-N-{1-[5-methoxy-3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methylbenzenesulfonamide; MS (ESI) 536 (MH+).

Workup

  1. customas prepared above in Example 5

Sources & evidence

ORD record
ord-a0b743b716344cbb8f96d5da299ccbd8
Source dataset
uspto-grants-2014_06
Patent number
US08748440B2

Reaction notes

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