反应详情

温度

55 °C

A mixture of 7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate (8.7 g, 0.037 mol), thionyl chloride (120 ml, 1.65 mol) and DMF (1 ml) was stirred and heated to 55° C. for 6 hours. The mixture was cooled to room temperature and thionyl chloride was evaporated. The solid was dissolved in chloroform and the solution was washed with sodium bicarbonate and brine, the chloroform was evaporated under reduced pressure to give 7.9 g of a gray product. MS (ESI) m/z: 253 (M+1).

1. temperatureThe mixture was cooled to room temperature
2. customthionyl chloride was evaporated
3. dissolutionThe solid was dissolved in chloroform
4. washthe solution was washed with sodium bicarbonate and brine
5. customthe chloroform was evaporated under reduced pressure