反应详情

A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (7.75 g, 0.0307 mol), 3-ethynyl aniline (4 g, 0.0342 mol, 1.11 equiv) and chloroform (120 ml) was refluxed overnight. The reaction mixture was cooled to room temperature and the solution was filtered to give 10.2 g product. MS (ESI) m/z: 334 (M+1).

1. temperaturewas refluxed overnight
2. filtrationthe solution was filtered