HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → HCID 86659918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-7-methoxyquinazolin-6-yl acetate | HCID 22022160 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 86659918 | HCID 86659918 | 89.8% |
Reaction Steps
A mixture of 4-chloro-7-methoxyquinazolin-6-yl acetate (7.75 g, 0.0307 mol), 3-ethynyl aniline (4 g, 0.0342 mol, 1.11 equiv) and chloroform (120 ml) was refluxed overnight. The reaction mixture was cooled to room temperature and the solution was filtered to give 10.2 g product. MS (ESI) m/z: 334 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08748453B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-8f3681ffb6ad484ea8cae4a59c2ee67d |
| Source note | uspto-grants-2014_06 |