3-Bromo-2-fluoropyridine → 3-Bromo-2-(tert-butoxy)pyridine

HRID 403669ノート

反応式

HRID 403669 の反応式
[Br:1][C:2]1[C:3](F)=[N:4][CH:5]=[CH:6][CH:7]=1.[CH3:9][C:10]([CH3:13])([O-:12])[CH3:11].[K+]>O1CCCC1>[Br:1][C:2]1[C:3]([O:12][C:10]([CH3:13])([CH3:11])[CH3:9])=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 27627783-Bromo-2-fluoropyridineHCID 23665647Potassium tert-butoxide

生成物 1

HCID 613737473-Bromo-2-(tert-butoxy)pyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-bromo-2-fluoropyridine (500 mg, 2.84 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was added potassium tert-butoxide (540 mg, 4.8 mmol) in portions over 30 minutes at 25° C., and stirring was continued for 4 hours at 25° C. The mixture was concentrated in vacuo and purified by silica gel flash chromatography eluting with dichloromethane/hexanes (50% to 100%) to give the title compound.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. custompurified by silica gel flash chromatography
  3. washeluting with dichloromethane/hexanes (50% to 100%)

出典と根拠

ORDレコード
ord-0763c82d1c184bd2a568fb0059e68e7a
出典データセット
uspto-grants-2014_06
特許番号
US08748443B2

反応ノート

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